LDHA-IN-9

LDHA-IN-9 (Compound 1g) is an inhibitor for LDH-A with an IC50 of 25 nM. LDHA-IN-9 inhibits the proliferation of DLD-1 cell (GI50 of 27 μM) through apoptosis induction. LDHA-IN-9 exhibits antitumor activity in mouse model without significant toxicity (25 mg/kg) [1].

Product Specifications

CAS Number

[862719-04-8]

UNSPSC

12352101

Target

Apoptosis; Lactate Dehydrogenase

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ldha-in-9.html

Smiles

BrC1=C2C(N(O)C(C(OC)=O)=C2COCCCCCC)=CC=C1

Molecular Formula

C17H22BrNO4

Molecular Weight

384.26

References & Citations

[1]Cheon SY, et al., Synthesis of 1-Hydroxy (and 1-Alkoxy, 1-Acyloxy) -1H-indoles and evaluations of their suppressive activities against tumor growth through inhibiting lactate dehydrogenase A. Eur J Med Chem. 2024 Nov 30;283:117104.