TAPI-1

TAPI-1 is a TACE (ADAM17) inhibitor and blocks the shedding of several cell surface proteins[1]. TAPI-1 is also a metalloproteinase (MMP) inhibitor[2].

Product Specifications

CAS Number

[163847-77-6]

UNSPSC

12352005

Hazard Statement

H301

Target

MMP

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/TAPI-1.html

Purity

99.36

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](CC1=CC=C2C=CC=CC2=C1)C(N[C@@H](C)C(NCCN)=O)=O)[C@H](CC(C)C)CC(NO)=O

Molecular Formula

C26H37N5O5

Molecular Weight

499.60

Precautions

H301

References & Citations

[1]Bae EH, et al. Tumor necrosis factor α-converting enzyme inhibitor attenuates lipopolysaccharide-induced reactive oxygen species and mitogen-activated protein kinase expression in human renal proximal tubule epithelial cells. Korean J Physiol Pharmacol. 2018 Mar;22 (2) :135-143.|[2]Moss ML, et al. Recent Advances in ADAM17 Research: A Promising Target for Cancer and Inflammation. Mediators Inflamm. 2017;2017:9673537.