OxLig-1

OxLig-1 (7-Ketocholesteryl-9-carboxynonanoate) is the lipid moiety of oxidized low-density lipoprotein (oxLDL) and is a key ligand for β-glycoprotein I (β (2) -GPI) . oxLig-1 causes nuclear translocation by activating the NF-κB pathway. oxLig-1 can be used in the study of atherosclerosis (AS) [1].

Product Specifications

CAS Number

[352523-18-3]

Product Name Alternative

7-Ketocholesteryl-9-carboxynonanoate

UNSPSC

12352211

Target

NF-κB

Type

Reference compound

Related Pathways

NF-κB

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/oxlig-1.html

Smiles

O=C1[C@]2([H])[C@@](CC[C@]3([C@@]2([H])CC[C@]3([H])[C@H](C)CCCC(C)C)C)([H])[C@@]4(C(C[C@H](CC4)OC(CCCCCCCC(O)=O)=O)=C1)C

Molecular Formula

C36H58O5

Molecular Weight

570.84

References & Citations

[1]Huang Z, et al. 7-ketocholesteryl-9-carboxynonanoate induced nuclear factor-kappa B activation in J774A.1 macrophages. Life Sci. 2010 Nov 20;87 (19-22) :651-7.