SB 452533

SB 452533 is a potent and selective TRPV1 antagonist with the pKb of 7.8[1].

Product Specifications

CAS Number

[459429-39-1]

UNSPSC

12352005

Hazard Statement

H302, H318, H410

Target

TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sb-452533.html

Purity

99.11

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NCCN(CC)C1=CC=CC(C)=C1)NC2=CC=CC=C2Br

Molecular Formula

C18H22BrN3O

Molecular Weight

376.29

Precautions

H302, H318, H410

References & Citations

[1]Harshad K Rami, et al. Discovery of small molecule antagonists of TRPV1. Bioorg Med Chem Lett. 2004 Jul 16;14 (14) :3631-4.|[2]Parisa Vahidi Ferdowsi, et al. TRPV1 Activation by Capsaicin Mediates Glucose Oxidation and ATP Production Independent of Insulin Signalling in Mouse Skeletal Muscle Cells. Cells. 2021 Jun 21;10 (6) :1560.|[3]Lin Ming Lu, et al. Effect of small dose capsaicin for treatment of pulmonary fibrosis in mice and its mechanism. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2020 May;36 (3) :216-222.