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P-2281

P-2281 is a mTOR inhibitor with anticancer and anti-inflammatory efficacies. P2281 inhibits mTOR activity in colon cancer cells. P-2281 suppresses Dextran sulfate sodium salt (DSS) -induced colitis by inhibiting T cell function and is efficacious in a murine model of human colitis[1].

Product Specifications

CAS Number

1112994-35-0

Product Name Alternative

ACT-179811

UNSPSC

12352005

Hazard Statement

H301, H311, H331, H341

Target

MTOR

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/p-2281.html

Purity

99.81

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

CC(C(NC1=CC=C(N=C1)C#N)=O)Cl

Molecular Formula

C9H8ClN3O

Molecular Weight

209.63

Precautions

H301, H311, H331, H341

References & Citations

[1]Mandar R Bhonde, et al. A novel mTOR inhibitor is efficacious in a murine model of colitis. Am J Physiol Gastrointest Liver Physiol. 2008 Dec;295 (6) :G1237-45.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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