5- (Pyridin-4-yl) -1,3,4-oxadiazole-2-thiol

5- (Pyridin-4-yl) -1,3,4-oxadiazole-2-thiol (Compound 3n) is an antimicrobial and antioxidant agent, that inhibits Escherichia coli and Staphylococcus epidermidis, with MIC of 8 and 4 μg/mL. 5- (Pyridin-4-yl) -1,3,4-oxadiazole-2-thiol exhibits antioxidant activity with IC50 of 17.47 μM using DPPH free radical-scavenging method[1].

Product Specifications

CAS Number

[15264-63-8]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Bacterial; Fungal

Type

Reference compound

Related Pathways

Anti-infection

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Infection; Metabolic Disease; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/5-pyridin-4-yl-1-3-4-oxadiazole-2-thiol.html

Purity

99.34

Solubility

10 mM in DMSO

Smiles

C1=C(C=CN=C1)C2=NN=C(O2)S

Molecular Formula

C7H5N3OS

Molecular Weight

179.20

Precautions

H315, H319, H335

References & Citations

[1]Yarmohammadi E, et al., Ultrasound-assisted, low-solvent and acid/base-free synthesis of 5-substituted 1,3,4-oxadiazole-2-thiols as potent antimicrobial and antioxidant agents. Mol Divers. 2021 Nov;25 (4) :2367-2378.