SR-3576
SR-3576 is a highly potent and selective JNK3 inhibitor with an IC50 of 7 nM[1].
Product Specifications
CAS Number
[1164153-22-3]
UNSPSC
12352005
Target
JNK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/sr-3576.html
Purity
99.75
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=CC=CC(NC(NC2=CN(C3=CC(C(NC4=CC(OC)=C(OC)C(OC)=C4)=O)=CC=C3)N=C2)=O)=C1
Molecular Formula
C27H27N5O5
Molecular Weight
501.53
References & Citations
[1]Kamenecka T, et al. Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38. J Biol Chem. 2009 May 8;284 (19) :12853-61.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JNK3
Available Sizes
Curated Selection
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