MS023 (dihydrochloride)
MS023 dihydrochloride is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC50s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively[1].
Product Specifications
CAS Number
1992047-64-9
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ms023-dihydrochloride.html
Purity
99.68
Solubility
DMSO : ≥ 150 mg/mL|H2O : 33.33 mg/mL (ultrasonic)
Smiles
CC(OC1=CC=C(C=C1)C2=CNC=C2CN(C)CCN)C.Cl.Cl
Molecular Formula
C17H27Cl2N3O
Molecular Weight
360.32
References & Citations
[1]Eram MS, et al. A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. ACS Chem Biol. 2016 Mar 18;11 (3) :772-81.|[2]Yinghui Zhu, et al. Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL-rearranged acute lymphoblastic leukemia. Blood. 2019 Oct 10;134 (15) :1257-1268.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PRMT1; PRMT3; PRMT6; PRMT8
Available Sizes
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