MS023 (dihydrochloride)

MS023 dihydrochloride is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC50s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively[1].

Product Specifications

CAS Number

[1992047-64-9]

UNSPSC

12352005

Target

Histone Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ms023-dihydrochloride.html

Purity

99.68

Solubility

DMSO : ≥ 150 mg/mL|H2O : 33.33 mg/mL (ultrasonic)

Smiles

CC(OC1=CC=C(C=C1)C2=CNC=C2CN(C)CCN)C.Cl.Cl

Molecular Formula

C17H27Cl2N3O

Molecular Weight

360.32

References & Citations

[1]Eram MS, et al. A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. ACS Chem Biol. 2016 Mar 18;11 (3) :772-81.|[2]Yinghui Zhu, et al. Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL-rearranged acute lymphoblastic leukemia. Blood. 2019 Oct 10;134 (15) :1257-1268.