PAR3 (1-6) (human)
Product Specifications
UNSPSC Description
PAR3 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 1 (PAR1) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR3 and residues 39-44 of the full-length human sequence. PAR3 (1-6) activates p42/44 MAPK signaling in fibroblasts expressing PAR1, but not PAR3, an effect that can be blocked by the PAR1 antagonist RWJ 56110.
Target Antigen
Protease Activated Receptor (PAR)
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/par3-1-6-human.html
Smiles
O=C(N(CCC1)[C@@H]1C(O)=O)[C@H](C)NC(CNC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H](N)[C@H](O)C)=O)CC2=CC=CC=C2)=O)=O)=O
Molecular Weight
647.72
References & Citations
[1]Kaufmann, et al. Proteinase-activated receptors (PARs) - The PAR3 neo-N-terminal peptide TFRGAP interacts with PAR1. Regul. Pept. 125(1-3), 61-66 (2005).
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P2380/PAR3-1-6-human-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P2380/
Clinical Information
No Development Reported
CAS Number
320347-28-2
Curated Selection
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