PAR3 (1-6) (human)

PAR3 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 1 (PAR1) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR3 and residues 39-44 of the full-length human sequence. PAR3 (1-6) activates p42/44 MAPK signaling in fibroblasts expressing PAR1, but not PAR3, an effect that can be blocked by the PAR1 antagonist RWJ 56110.

Product Specifications

CAS Number

[320347-28-2]

Product Name Alternative

TFRGAP

UNSPSC

12352209

Target

Protease Activated Receptor (PAR)

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/par3-1-6-human.html

Smiles

O=C(N(CCC1)[C@@H]1C(O)=O)[C@H](C)NC(CNC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H](N)[C@H](O)C)=O)CC2=CC=CC=C2)=O)=O)=O

Molecular Formula

C29H45N9O8

Molecular Weight

647.72

References & Citations

[1]Kaufmann, et al. Proteinase-activated receptors (PARs) - The PAR3 neo-N-terminal peptide TFRGAP interacts with PAR1. Regul. Pept. 125 (1-3), 61-66 (2005) .