Canrenoate (potassium)

Canrenoate (Aldadiene) potassium, a proagent that releases canrenone, is a potent, competitive mineralocorticoid receptor (aldosterone receptor) antagonist. Potassium canrenoate, as a diuretic, is used for the research of hypertension[1][2][3].

Product Specifications

CAS Number

[2181-04-6]

Product Name Alternative

Aldadiene (potassium) ; SC-14266

UNSPSC

12352211

Hazard Statement

H302

Target

Mineralocorticoid Receptor

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/canrenoate-potassium.html

Purity

99.89

Solubility

DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C[C@@]12[C@@](CCC(O[K])=O)(O)CC[C@@]1([H])[C@]3([H])C=CC4=CC(CC[C@]4(C)[C@@]3([H])CC2)=O

Molecular Formula

C22H29KO4

Molecular Weight

396.56

Precautions

H302

References & Citations

[1]Iqbal J, Andrew R, et al. Displacement of cortisol from human heart by acute administration of a mineralocorticoid receptor antagonist. J Clin Endocrinol Metab. 2014;99 (3) :915-922.