IWR-1
Product Specifications
Product Name Alternative
endo-IWR 1; IWR-1-endo
UNSPSC Description
IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway.
Target Antigen
Organoid; Wnt
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/IWR-1.html
Purity
99.49
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(NC1=C2N=CC=CC2=CC=C1)C3=CC=C(N(C([C@]4([H])[C@](C5)([H])C=C[C@]5([H])[C@]64[H])=O)C6=O)C=C3
Molecular Weight
409.44
References & Citations
[1]Lu J, et al. Structure-activity relationship studies of small-molecule inhibitors of Wnt response. Bioorg Med Chem Lett. 2009 Jul 15;19(14):3825-7.|[2]Zhang X, et al. Macrophage migration inhibitory factor promotes proliferation and neuronal differentiation of neural stem/precursor cells through Wnt/β-catenin signal pathway. Int J Biol Sci. 2013 Nov 28;9(10):1108-20.|[3]Gupta PS, et al. Regulation and Regulatory Role of WNT Signaling in Potentiating FSH Action during Bovine Dominant Follicle Selection. PLoS One. 2014 Jun 17;9(6):e100201.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12238/IWR-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12238/IWR-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1127442-82-3
Available Sizes
Curated Selection
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