Substance P (1-7) (TFA)

Substance P (1-7) TFA is a fragment of the neuropeptide, substance P (SP) . Substance P (1-7) TFA gives depressor and bradycardic effects when applied to the nucleus tractus solitarius[1].

Product Specifications

CAS Number

[2828433-22-1]

UNSPSC

12352209

Hazard Statement

H302-H315-H319-H335

Target

Neurokinin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Substance_P__1-7__TFA_.html

Purity

99.14

Solubility

H2O : ≥ 50 mg/mL

Smiles

O=C(N1[C@@H](CCC1)C(N[C@@H](CCCCN)C(N2[C@@H](CCC2)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC3=CC=CC=C3)C(O)=O)=O)=O)=O)=O)=O)[C@H](CCCNC(N)=N)N.OC(C(F)(F)F)=O

Molecular Formula

C43H66F3N13O12

Molecular Weight

1014.06

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Herrera-Marschitz M, et al. The substance P (1-7) fragment is a potent modulator of substance P actions in the brain. Brain Res. 1990 Jun 25;521 (1-2) :316-20.|[2]Sakurada T, et al. Substance P (1-7) antagonizes substance P-induced aversive behaviour in mice. Neurosci Lett. 1988 Dec 19;95 (1-3) :281-5.