ZT-12-037-01
ZT-12-037-01 is a STK19-targeted inhibitor, has a high-affinity interaction with STK19 protein and inhibits oncogenic NRAS-driven melanocyte malignant transformation. ZT-12-037-01 is an ATP-competitive inhibitor, inhibiting phosphorylation of NRAS (major isoform of Ras family) with an IC50 of 24 nM[1].
Product Specifications
CAS Number
[2328073-61-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Ras; Ser/Thr Kinase
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/zt-12-037-01.html
Purity
98.06
Solubility
1M HCl : 100 mg/mL (ultrasonic) |DMSO : 50 mg/mL (ultrasonic; adjust pH to 2 with 1M HCl)
Smiles
COC1=CC2=NC(NC3CC3)=NC(NC4CCN(C(C)C)CC4)=C2C=C1OC
Molecular Formula
C21H31N5O2
Molecular Weight
385.50
Precautions
H302, H315, H319, H335
References & Citations
[1]Yin C, et al. Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven Melanomagenesis. Cell. 2019 Feb 21;176 (5) :1113-1127.e16.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STK19
Available Sizes
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