Perospirone (hydrochloride)

Perospirone hydrochloride (SM-9018) is an orally active antagonist of 5-HT2A receptor (Ki of 0.6 nM) and dopamine D2 receptor (Ki of 1.4 nM) . Perospirone hydrochloride is also a partial agonist of 5-HT1A receptor (Ki of 2.9 nM) . Perospirone hydrochloride is an atypical antipsychotic agent and has the potential for schizophrenic disease research[1][2].

Product Specifications

CAS Number

[129273-38-7]

Product Name Alternative

SM-9018

UNSPSC

12352005

Hazard Statement

H302

Target

5-HT Receptor; Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/perospirone-hydrochloride.html

Concentration

10mM

Purity

99.94

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

[H]Cl.O=C([C@@]1([H])[C@]2([H])CCCC1)N(C2=O)CCCCN3CCN(C4=NSC5=C4C=CC=C5)CC3

Molecular Formula

C23H31ClN4O2S

Molecular Weight

463.04

Precautions

H302

References & Citations

[1]Kato T, et al. Binding profile of SM-9018, a novel antipsychotic candidate. pn J Pharmacol. 1990 Dec;54 (4) :478-81.|[2]Hagiwara H, et al. Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antipsychotic drug perospirone: role of serotonin 5-HT1A receptors. Eur Neuropsychopharmacol. 2008 Jun;18 (6) :448-54.