Metoprolol-d6 (succinate)
Metoprolol-d6 (succinate) is deuterium labeled Metoprolol (succinate) . Metoprolol succinate is an orally active, selective β1-adrenoceptor antagonist. Metoprolol succinate shows anti-inflammation, antitumor and anti-angiogenic properties[1][2][3][4].
Product Specifications
UNSPSC
12352005
Target
Adrenergic Receptor; Apoptosis; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Cardiovascular Disease; Endocrinology; Cancer
Smiles
OC(CNC(C([2H])([2H])[2H])C([2H])([2H])[2H])COC1=CC=C(CCOC)C=C1.O=C(O)CCC(O)=O
Molecular Formula
C19H25D6NO7
Molecular Weight
391.49
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Ulleryd MA, et al. Metoprolol reduces proinflammatory cytokines and atherosclerosis in ApoE-/- mice. Biomed Res Int. 2014;2014:548783.|[3]Wang D, et al. Carvedilol has stronger anti-inflammation and anti-virus effects than metoprolol in murine model with coxsackievirus B3-induced viral myocarditis. Gene. 2014 Sep 1;547 (2) :195-201.|[4]Hajatbeigi B, et al. Cytotoxicity of Metoprolol on Leukemic Cells in Vitro. IJBC 2018; 10 (4) : 124-129.|[5]Su Q, et al. Effect of metoprolol on myocardial apoptosis and caspase-9 activation after coronary microembolization in rats. Exp Clin Cardiol. 2013 Spring;18 (2) :161-5.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
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