Procyanidin B2

Procyanidin B2 is a natural flavonoid, with anti-cancer, antioxidant activities.

Product Specifications

CAS Number

[29106-49-8]

Product Name Alternative

Proanthocyanidin B2

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Procyanidin-B2.html

Purity

99.89

Solubility

DMSO : ≥ 50 mg/mL|H2O : 66.67 mg/mL (ultrasonic)

Smiles

O[C@H]1[C@@H](C2=CC=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C3[C@@H]1C4=C5C(C[C@@H](O)[C@@H](C6=CC=C(O)C(O)=C6)O5)=C(O)C=C4O

Molecular Formula

C30H26O12

Molecular Weight

578.52

Precautions

H302, H315, H319, H335

References & Citations

[1]Avelar MM, et al. Procyanidin b2 cytotoxicity to mcf-7 human breast adenocarcinoma cells. Indian J Pharm Sci. 2012 Jul;74 (4) :351-5.|[2]Yang H, et al. Procyanidin B2 inhibits NLRP3 inflammasome activation in human vascular endothelial cells. Biochem Pharmacol. 2014 Dec 15;92 (4) :599-606.|[3]Wu S, et al. Procyanidin B2 attenuates neurological deficits and blood-brain barrier disruption in a rat model of cerebral ischemia. Mol Nutr Food Res. 2015 Oct;59 (10) :1930-41.