NaV1.7 inhibitor-1
NaV1.7 inhibitor-1 is an efficacious voltage-gated sodium channel (NaV) 1.7 inhibitor with an IC50 of 0.6 nM for hNaV1.7, exhibits 80-fold selectivity versus hNaV1.5[1].
Product Specifications
CAS Number
[1494585-79-3]
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nav1-7-inhibitor-1.html
Purity
99.17
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
FC1=CC(OCC2(C)CCC3(CC3)CC2)=C(C4CC4)C=C1C(NS(C5CC5)(=O)=O)=O
Molecular Formula
C23H30FNO4S
Molecular Weight
435.55
References & Citations
[1]Sun S, Identification of Selective Acyl Sulfonamide-Cycloalkylether Inhibitors of the Voltage-GatedSodium Channel (NaV) 1.7 with Potent Analgesic Activity. J Med Chem. 2019 Jan 24;62 (2) :908-927.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Nav1.7
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
K0979203 1.0 µg DNA
HNRPUP sgRNA CRISPR Lentivector (Human) (Target 2)
Sign In for Pricing
View Details 
NHFF-0524-HX477 Each
Monkeypox Virus Recombinant I1L Protein (N-His)
Sign In for Pricing
View Details GTR15370957 1 Vial
Lentiviral human TLDC2 sgRNA gene knockout kit - Lentiviral human TLDC2 sgRNA gene knockout kit (100)
Sign In for Pricing
View Details 
K0522003 1.0 µg DNA
CT45A6 sgRNA CRISPR Lentivector (Human) (Target 2)
Sign In for Pricing
View Details K0958607 1.0 µg DNA
HIST1H3I sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)
Sign In for Pricing
View Details 
MBS7161531 Inquire
Rabbit anti-Escherichia coli O6:H1 (strain CFT073/700928/UPEC) MLAE Polyclonal Antibody
Sign In for Pricing
View Details