2,2,2-Trifluoro-N-methyl-N- (trimethylsilyl) acetamide

2,2,2-Trifluoro-N-methyl-N- (trimethylsilyl) acetamide (N-Methyl-n-trimethylsilyltrifluoroacetamide) is an ester product commonly used for silylation reactions in analyticalchemistry. 2,2,2-Trifluoro-N-methyl-N- (trimethylsilyl) acetamide can be used in the derivatization step of metabolomics analysis with gas chromatography/mass spectrometry (GC/MS) or as a derivatization reagent in GC with flame ionization detection analysis. 2,2,2-Trifluoro-N-methyl-N- (trimethylsilyl) acetamide can be used in research for studying Tamoxifen (HY-13757A) resistant breast cancer cells and other disease pathways[1][2][3].

Product Specifications

CAS Number

[24589-78-4]

Product Name Alternative

N-Methyl-n-trimethylsilyltrifluoroacetamide

UNSPSC

12352211

Hazard Statement

H226, H315, H319, H335

Target

Others

Type

Natural Products

Related Pathways

Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/2-2-2-trifluoro-n-methyl-n-trimethylsilyl-acetamide.html

Concentration

10mM

Purity

98.79

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C(N(C)[Si](C)(C)C)C(F)(F)F

Molecular Formula

C6H12F3NOSi

Molecular Weight

199.25

Precautions

H226, H315, H319, H335

References & Citations

[1]Böröczky, K., et al., (2006) . Cluster analysis as selection and dereplication tool for the identification of new natural compounds from large sample sets. Chemistry & biodiversity, 3 (6), 622–634.|[2]Müller, C., et al., (2019) . A gas chromatography-mass spectrometry-based whole-cell screening assay for target identification in distal cholesterol biosynthesis. Nature protocols, 14 (8), 2546–2570.|[3]Mishra, A., et al., (2024) . Comparative metabolomics of MCF-7 and MCF-7/TAMR identifies potential metabolic pathways in tamoxifen resistant breast cancer cells. American journal of translational research, 16 (4), 1337–1352.