Crisdesalazine

Crisdesalazine (AAD-2004) is an anti-inflammatory agent that simultaneously blocks inflammation mediated by free radicals and prostaglandin E2 (PGE2) . Crisdesalazine (AAD-2004) can be used to study neurodegeneration in amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases[1].

Product Specifications

CAS Number

[927685-43-6]

Product Name Alternative

AAD-2004

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/crisdesalazine.html

Purity

98.92

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC(C1=CC(NCCC2=CC=C(C(F)(F)F)C=C2)=CC=C1O)=O

Molecular Formula

C16H14F3NO3

Molecular Weight

325.28

Precautions

H302, H315, H319, H335

References & Citations

[1]Shin JH, et al. Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis. J Neurochem. 2012 Sep;122 (5) :952-61.