Nafcillin (sodium monohydrate)

Nafcillin sodium monohydrate, an antibiotic, is a reversible inhibitor of β-lactamase. Nafcillin sodium monohydrate can be used for the research of staphylococcal infections[1][2].

Product Specifications

CAS Number

[7177-50-6]

UNSPSC

12352005

Hazard Statement

H315, H317, H319, H334, H335

Target

Antibiotic; Bacterial; Beta-lactamase

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Nafcillin-sodium-monohydrate.html

Purity

98.10

Solubility

H2O : 5.83 mg/mL (ultrasonic)

Smiles

O=C([C@@H]1N(C2=O)[C@]([C@@H]2NC(C(C3=CC=CC=C3C=C4)=C4OCC)=O)([H])SC1(C)C)O[Na].O

Molecular Formula

C21H23N2NaO6S

Molecular Weight

454.47

Precautions

H315, H317, H319, H334, H335

References & Citations

[1]Tan, A.K., et al. Identification of the site of covalent attachment of nafcillin, a reversible suicide inhibitor of beta-lactamase. Biochem J, 1992. 281 (Pt 1) : p. 191-6.|[2]Palmer, D.L., et al. Bacterial wound colonization after broad-spectrum versus narrow-spectrum antibiotics. Ann Thorac Surg, 1995. 59 (3) : p. 626-31.|[3]Lawrence I. Mortin, et al. Rapid Bactericidal Activity of Daptomycin against Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus Peritonitis in Mice as Measured with Bioluminescent Bacteria. Antimicrob Agents Chemother. 2007 May; 51 (5) : 1787-1794.