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N-Ac-γ-Calicheamicin-AcBut-NHS ester

AcBut-N-Ac-γ-Calicheamicin is an ADC cytotoxic payload that induces cell cycle arrest and apoptosis by causing DNA double-strand breaks. AcBut-N-Ac-γ-Calicheamicin is primarily used in the synthesis of antibody-drug conjugates (ADC) and holds promise for research in the field of cancer, including acute lymphoblastic leukemia (ALL) and other hematological malignancies[1].

Product Specifications

CAS Number

[174885-02-0]

UNSPSC

12352005

Hazard Statement

H300, H310, H315, H319, H330, H335, H351

Target

ADC Payload

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n-ac-γ-calicheamicin-acbut-nhs-ester.html

Purity

95.62

Smiles

O[C@](CC1=O)(C#C/C=C\C#C2)/C(C([C@H]2O[C@@](O[C@H](C)[C@@H](NO[C@H](O[C@H](C)[C@H]3SC(C(C(C)=C(I)C(O[C@H](O[C@@H](C)[C@H](O)[C@H]4OC)[C@@H]4O)=C5OC)=C5OC)=O)C[C@@H]3O)[C@@H]6O)([H])[C@@H]6O[C@@](OC[C@@H]7N(CC)C(C)=O)([H])C[C@@H]7OC)=C1NC(OC)=O)=C/CSSC(C)(C)CC(N/N=C(C8=CC=C(OCCCC(ON(C9=O)C(CC9)=O)=O)C=C8)\C)=O

Molecular Formula

C77H99IN6O28S3

Molecular Weight

1779.73

Precautions

H300, H310, H315, H319, H330, H335, H351

References & Citations

[1]Lamb Y N. Inotuzumab ozogamicin: first global approval[J]. Drugs, 2017, 77: 1603-1610.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture and light)

Badge

Hot

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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