BRAFV600E-IN-1
BRAFV600E-IN-1 (compound 9S) is a BRAF inhibitor. BRAFV600E-IN-1 has a significant apoptosis-inducing effect in cell lines expressing mutant KRAS and cancer cells expressing BRAFV600E[1].
Product Specifications
UNSPSC
12352211
Target
Raf
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/brafv600e-in-1.html
Smiles
O=C(NC1=CC=C(Cl)C(Cl)=C1)NC2=CC=C(OCC(N/N=C3C(NC4=C\3C=C(Cl)C=C4)=O)=O)C=C2
Molecular Formula
C23H16Cl3N5O4
Molecular Weight
532.76
References & Citations
[1]Ghannam IAY, et al. Discovery of novel diaryl urea-oxindole hybrids as BRAF kinase inhibitors targeting BRAF and KRAS mutant cancers. Bioorg Chem. 2024 Sep 26;153:107848.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
B-Raf
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