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BRAFV600E-IN-1

BRAFV600E-IN-1 (compound 9S) is a BRAF inhibitor. BRAFV600E-IN-1 has a significant apoptosis-inducing effect in cell lines expressing mutant KRAS and cancer cells expressing BRAFV600E[1].

Product Specifications

UNSPSC

12352211

Target

Raf

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/brafv600e-in-1.html

Smiles

O=C(NC1=CC=C(Cl)C(Cl)=C1)NC2=CC=C(OCC(N/N=C3C(NC4=C\3C=C(Cl)C=C4)=O)=O)C=C2

Molecular Formula

C23H16Cl3N5O4

Molecular Weight

532.76

References & Citations

[1]Ghannam IAY, et al. Discovery of novel diaryl urea-oxindole hybrids as BRAF kinase inhibitors targeting BRAF and KRAS mutant cancers. Bioorg Chem. 2024 Sep 26;153:107848.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

B-Raf

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