PROTAC EGFR degrader 3
Product Specifications
UNSPSC Description
PROTAC EGFR degrader 3 is a potent PROTAC EGFR degrader. PROTAC EGFR degrader 3 shows excellent cellular activity against the H1975 and HCC827 cells with high selectively. PROTAC EGFR degrader 3 shows that the lysosome is involved in the degradation process of EGFR mutant degradation[1].
Target Antigen
EGFR; PROTACs
Type
Reference compound
Related Pathways
JAK/STAT Signaling;PROTAC;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-egfr-degrader-3.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C=CC(N1CCC[C@@H](C1)N2C3=C(N=C2NC4=CC=CC=C4)C=NC(NC5=CC=C(C=C5)N6CCN(CC6)CCCCCCCC(N[C@H](C(N7[C@@H](C[C@H](C7)O)C(N[C@H](C8=CC=C(C=C8)C9=C(N=CS9)C)C)=O)=O)C(C)(C)C)=O)=N3)=O
Molecular Weight
1092.40
References & Citations
[1]Zhao HY, et al. Discovery of Potent PROTACs Targeting EGFR Mutants through the Optimization of Covalent EGFR Ligands. J Med Chem. 2022; 65(6):4709-4726.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-144605/PROTAC-EGFR-degrader-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-144605/PROTAC-EGFR-degrader-3-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2768472-28-0
Available Sizes
Curated Selection
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