GT-653
GT-653 is a PROTAC degrader for lysine-specific demethylase 5B (KDM5B). GT-653 degrades 68.35% KDM5B at 10 μM in a ubiquitin proteasome-dependent manner, upregulates H3K4me3 levels, and activates the type-I interferon signaling pathway in prostate cancer cells 22RV1. (Pink: KDM5B ligand ; Black: Linker (HY-W004896) ; Blue: E3 ligase ligand (HY-103596) )
Product Specifications
UNSPSC
12352005
Target
Histone Demethylase; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gt-653.html
Purity
99.84
Solubility
10 mM in DMSO
Smiles
N#CC1=C2NC(C3=CC=C(C=C3)OCC(NCCOCCOC4=CC=CC5=C4C(N(C5=O)C6CCC(NC6=O)=O)=O)=O)=CC(N2N=C1)=O
Molecular Formula
C32H27N7O9
Molecular Weight
653.60
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Kremen, NT (Kremen protein 1, Kringle-containing Protein Marking The Eye And The Nose, Kringle Domain-containing Transmembrane Protein 1, Dickkopf Receptor, KREMEN1, KRM1) (MaxLight 750) discontinued
![Mouse Monoclonal GIMAP4 Antibody (OTI1C6) [Alexa Fluor 532]](https://cdn.genprice.uk/genprice/uk/genprice4.webp)
Mouse Monoclonal GIMAP4 Antibody (OTI1C6) [Alexa Fluor 532]
![Rabbit Polyclonal IDI2 Antibody [DyLight 350]](https://cdn.genprice.uk/genprice/uk/genprice3.webp)