Ginkgolic acid C17:1

Ginkgolic acid C17:1 is a fatty acid synthase (FAS) inhibitor with an IC50 of 10.5 µM. Ginkgolic acid C17:1 shows anti-tumor activity by inhibiting the phosphorylation of STAT3 and inducing apoptosis. Ginkgolic acid C17:1 can block the interaction between S-RBD and ACE2, and has anti-SARS-CoV-2-S pseudovirus activity. Ginkgolic acid C17:1 inhibits the biofilm formation of enterohemorrhagic Escherichia coli and Staphylococcus aureus[1][2][3][4][5].

Product Specifications

CAS Number

[111047-30-4]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Apoptosis; Fatty Acid Synthase (FASN) ; PTEN; SARS-CoV; STAT

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; JAK/STAT Signaling; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/ginkgolic-acid-c17-1.html

Purity

99.80

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)C1=C(O)C=CC=C1CCCCCCCCC/C=C\CCCCCC

Molecular Formula

C24H38O3

Molecular Weight

374.56

Precautions

H315, H319, H335

References & Citations

[1]Baek SH, et al. Ginkgolic Acid C 17:1, Derived from Ginkgo biloba Leaves, Suppresses Constitutive and Inducible STAT3 Activation through Induction of PTEN and SHP-1 Tyrosine Phosphatase. Molecules. 2017 Feb 13;22 (2) . pii: E276.|[2]Xiang Y, et al. Ginkgolic acids inhibit SARS-CoV-2 and its variants by blocking the spike protein/ACE2 interplay. Int J Biol Macromol. 2023 Jan 31;226:780-792. |[3]Lee JH, et al. Ginkgolic acids and Ginkgo biloba extract inhibit Escherichia coli O157:H7 and Staphylococcus aureus biofilm formation. Int J Food Microbiol. 2014 Mar 17;174:47-55.|[4]Yang XM, et al. Thermal stability of ginkgolic acids from Ginkgo biloba and the effects of ginkgol C17:1 on the apoptosis and migration of SMMC7721 cells. Fitoterapia. 2014 Oct;98:66-76. |[5]Oh J, et al. Inhibition of fatty acid synthase by ginkgolic acids from the leaves of Ginkgo biloba and their cytotoxic activity. J Enzyme Inhib Med Chem. 2013 Jun;28 (3) :565-8.