JYQ-194

JYQ-194 is a PROTAC degrader targeting human Parkinson's disease protein 7 (PARK7) . JYQ-194 can be used in the study of cancer and neurodegenerative diseases. (Pink: PARK7 ligand (HY-163563) ; Black: linker (HY-W017440) ; Blue: E3 ligase ligand (HY-10984) ) [1].

Product Specifications

UNSPSC

12352005

Target

PROTACs

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/jyq-194.html

Purity

98.05

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C([C@H]1CN(C#N)CC1)NC(S2)=NC3=C2CN(C(C4=C(F)C=CC(N5C=C(COCCOCCNC6=C(C(N(C7CCC(NC7=O)=O)C8=O)=O)C8=CC=C6)N=N5)=C4)=O)CC3

Molecular Formula

C39H38FN11O8S

Molecular Weight

839.85

References & Citations

[1]Jia Y, et al. Development of Inhibitors, Probes, and PROTAC Provides a Complete Toolbox to Study PARK7 in the Living Cell[J]. Journal of Medicinal Chemistry, 2024.