HDL376

HDL376 is a scavenger receptor class B type I (SR-BI) inhibitor. HDL376 directly inhibits SR-BI-mediated lipid transport in cells and in liposomes reconstituted with purified SR-BI (IC50 = 0.22 μM) . HDL376 can be used for the research of atherosclerotic coronary artery disease[1].

Product Specifications

CAS Number

[147751-31-3]

Product Name Alternative

SDZ-HDL 376

UNSPSC

12352005

Hazard Statement

H302, H312, H315, H319, H332, H335

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/hdl376.html

Purity

98.62

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

S=C(NC1=CC(Cl)=CC=C1C)NCC(C)C

Molecular Formula

C12H17ClN2S

Molecular Weight

256.79

Precautions

H302, H312, H315, H319, H332, H335

References & Citations

[1]Nieland TJ, et al. Influence of HDL-cholesterol-elevating drugs on the in vitro activity of the HDL receptor SR-BI. J Lipid Res. 2007 Aug;48 (8) :1832-45.