HDL376
HDL376 is a scavenger receptor class B type I (SR-BI) inhibitor. HDL376 directly inhibits SR-BI-mediated lipid transport in cells and in liposomes reconstituted with purified SR-BI (IC50 = 0.22 μM) . HDL376 can be used for the research of atherosclerotic coronary artery disease[1].
Product Specifications
CAS Number
147751-31-3
Product Name Alternative
SDZ-HDL 376
UNSPSC
12352005
Hazard Statement
H302, H312, H315, H319, H332, H335
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/hdl376.html
Purity
98.62
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
S=C(NC1=CC(Cl)=CC=C1C)NCC(C)C
Molecular Formula
C12H17ClN2S
Molecular Weight
256.79
Precautions
H302, H312, H315, H319, H332, H335
References & Citations
[1]Nieland TJ, et al. Influence of HDL-cholesterol-elevating drugs on the in vitro activity of the HDL receptor SR-BI. J Lipid Res. 2007 Aug;48 (8) :1832-45.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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