AZP-531

AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight.

Product Specifications

CAS Number

[1088543-62-7]

UNSPSC

12352209

Target

GHSR

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/AZP-531.html

Purity

99.79

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

O=C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]1CCCNC(N)=N)=O)C(C)C)=O)CCC(N)=O)=O)CO)N(CCC2)[C@]2([H])C(N[C@H](C(N[C@H](C(N[C@H](C(N1)=O)CCC(N)=O)=O)CC3=CN=CN3)=O)CCC(O)=O)=O

Molecular Formula

C40H63N15O13

Molecular Weight

962.02

References & Citations

[1]Julien M, et al. In vitro and in vivo stability and pharmacokinetic profile of unacylated ghrelin (UAG) analogues. Eur J Pharm Sci. 2012 Nov 20;47 (4) :625-35.|[2]Delhanty PJ, et al. Des-acyl ghrelin analogs prevent high-fat-diet-induced dysregulation of glucosehomeostasis. FASEB J. 2013 Apr;27 (4) :1690-700.|[3]Allas S, et al. Safety, tolerability, pharmacokinetics and pharmacodynamics of AZP-531, a first-in-class analogue of unacylated ghrelin, in healthy and overweight/obese subjects and subjects with type 2 diabetes. Diabetes Obes Metab. 2016 Sep;18 (9) :868-74.