Furamidine (dihydrochloride)
Furamidine dihydrochloride (DB75 dihydrochloride) is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 μM. Furamidine dihydrochloride is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC50s of 166 μM, 283 μM, and >400 μM, respectively) . Furamidine dihydrochloride is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1 by Furamidine dihydrochloride is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA. Furamidine dihydrochloride is also an antiparasite agent[1][2][3].
Product Specifications
CAS Number
55368-40-6
Product Name Alternative
DB75 (dihydrochloride) ; NSC 305831 (dihydrochloride)
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Histone Methyltransferase; Parasite; Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Anti-infection; Epigenetics; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/furamidine-dihydrochloride.html
Purity
99.0
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
N=C(C1=CC=C(C2=CC=C(C3=CC=C(C(N)=N)C=C3)O2)C=C1)N.[H]Cl.[H]Cl
Molecular Formula
C18H18Cl2N4O
Molecular Weight
377.27
Precautions
H315, H319, H335
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PRMT1
Citation 01
Cell Rep. 2024 Aug 22;43 (9) :114662.|Int Immunopharmacol. 2025 Aug 8:164:115327.|Research Square Print. September 20th, 2022.
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