CARM1/HDAC2-IN-1
CARM1/HDAC2-IN-1 (compound CH-1) is a dual inhibitor against CARM1 and HDAC2, with IC50 values of 3.71 nM and 4.07 nM, respectively. CARM1/HDAC2-IN-1 possesses antitumor activity[1].
Product Specifications
UNSPSC
12352005
Target
HDAC; Histone Methyltransferase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/carm1-hdac2-in-1.html
Concentration
10mM
Purity
95.17
Solubility
10 mM in DMSO
Smiles
CNCCNCC1=CC=CC(C2=NC(NC3=CC(OCCCCCCC(NO)=O)=CC=C3)=C(C(C4=C5C=CNC5=NC=C4)=N2)C)=C1
Molecular Formula
C35H42N8O3
Molecular Weight
622.76
References & Citations
[1]Liang S, et al. Discovery and biological evaluation of novel CARM1/HDAC2 dual-targeting inhibitors with anti-prostate cancer agents. J Enzyme Inhib Med Chem. 2023 Dec;38 (1) :2241118.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC2
Available Sizes
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