CARM1/HDAC2-IN-1

CARM1/HDAC2-IN-1 (compound CH-1) is a dual inhibitor against CARM1 and HDAC2, with IC50 values of 3.71 nM and 4.07 nM, respectively. CARM1/HDAC2-IN-1 possesses antitumor activity[1].

Product Specifications

UNSPSC

12352005

Target

HDAC; Histone Methyltransferase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/carm1-hdac2-in-1.html

Concentration

10mM

Purity

95.17

Solubility

10 mM in DMSO

Smiles

CNCCNCC1=CC=CC(C2=NC(NC3=CC(OCCCCCCC(NO)=O)=CC=C3)=C(C(C4=C5C=CNC5=NC=C4)=N2)C)=C1

Molecular Formula

C35H42N8O3

Molecular Weight

622.76

References & Citations

[1]Liang S, et al. Discovery and biological evaluation of novel CARM1/HDAC2 dual-targeting inhibitors with anti-prostate cancer agents. J Enzyme Inhib Med Chem. 2023 Dec;38 (1) :2241118.