PDK1-IN-2

PDK1-IN-2 is a small molecule inhibitor of 3-phosphoinositol-dependent protein kinase-1 (PDK1) . PDK1-IN-2 inhibits the binding of PDK1 to its substrate by competitively binding to the PIF pocket of PDK1, thereby inhibiting the kinase activity and downstream signaling of PDK1. PDK1-IN-2 can be used for cell survival and proliferation in cancer[1].

Product Specifications

CAS Number

[1643958-85-3]

Product Name Alternative

MKS 492

UNSPSC

12352005

Target

PDK-1

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pdk1-in-2.html

Purity

98.90

Solubility

DMSO : 4 mg/mL (ultrasonic; warming)

Smiles

O=S(NC1=NC2=C(S1)C=C(Cl)C=C2)(C3=CSC4=C3C=CC=C4)=O

Molecular Formula

C15H9ClN2O2S3

Molecular Weight

380.89

References & Citations

[1]Rettenmaier T J, et al. A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1[J]. Proceedings of the National Academy of Sciences, 2014, 111 (52) : 18590-18595.