PDK1-IN-2
Product Specifications
Product Name Alternative
MKS 492
UNSPSC Description
PDK1-IN-2 is a small molecule inhibitor of 3-phosphoinositol-dependent protein kinase-1 (PDK1). PDK1-IN-2 inhibits the binding of PDK1 to its substrate by competitively binding to the PIF pocket of PDK1, thereby inhibiting the kinase activity and downstream signaling of PDK1. PDK1-IN-2 can be used for cell survival and proliferation in cancer[1].
Target Antigen
PDK-1
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pdk1-in-2.html
Purity
98.90
Solubility
DMSO : 4 mg/mL (ultrasonic;warming)
Smiles
O=S(NC1=NC2=C(S1)C=C(Cl)C=C2)(C3=CSC4=C3C=CC=C4)=O
Molecular Weight
380.89
References & Citations
[1]Rettenmaier T J, et al. A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1[J]. Proceedings of the National Academy of Sciences, 2014, 111(52): 18590-18595.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-117809/PDK1-IN-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-117809/PDK1-IN-2-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1643958-85-3
Available Sizes
Curated Selection
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