PDE5-IN-9

PDE5-IN-9 (Compound 59) is a PDE5 inhibitor (IC50: 11.2 μM) . PDE5-IN-9 shows interaction with Gln 817, Tyr 612, and Ala 767 amino acid residues. PDE5-IN-9 can be used for research of cardiovascular disease[1].

Product Specifications

CAS Number

[157862-84-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/pde5-in-9.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C1(C2=CC=CN=C2)=NC(NCC3=CC=CS3)=C4C=CC=CC4=N1

Molecular Formula

C18H14N4S

Molecular Weight

318.40

Precautions

H302, H315, H319

References & Citations

[1]Sarvesh Paliwal, et al. Pharmacophore and molecular docking based identification of novel structurally diverse PDE-5 inhibitors. Medicinal Chemistry Research. 2015, 24, 576-587.