Anti-APRIL (ED2) Antibody

Rabbit Polyclonal Antibody specific to APRIL (ED2)

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

A proliferation-inducing ligand, APRIL, TNF- and APOL-related leukocyte expressed ligand 2, TALL-2, TNF-related death ligand 1, TRDL-1, CD antigen CD256

Gene Name

TNFSF13

NCBI Gene ID

<a href="https://www.ncbi.nlm.nih.gov/gene/?term=TNFSF13">TNFSF13</a>

UniProt

O75888

Cellular Locus

Secreted

Host

Rabbit

Reactivity

Human, Drosophila

Immunogen

Peptide corresponding to aa 180-230 of human April

Target Antigen

Tumor necrosis factor ligand superfamily member 13

Target

APRIL (ED2)

Clonality

Polyclonal

Type

Antibody

Applications

ELISA, WB, IHC-P

Field of Research

Growth Factors, Cytokines, Receptors

Purification Method

Purified by peptide immuno-affinity chromatography

Concentration

1.0 mg/mL

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes. {PubMed:10973284}.

Additionnal Information

Immunoblotting: use at 1-4 ug/mL. A band of ~27kDa is detected. <br><br>Immunohistochemistry: use at 10ug/mL.

Storage Conditions

This antibody is stable for three months at 4°C and at least one year at -20°C. Store in appropriate aliquots to avoid multiple freeze-thaw cycles.

Specificity

Human and mouse APRIL. Reactivity with other species has not been investigated.

Formulation

PBS, 0.02% sodium azide.

Target Background

APRIL (A Proliferation-Inducing Ligand) is a member of the TNF superfamily identified in human and mouse. Two receptors for APRIL have been designated TACI and BCMA. APRIL stimulates B and T cell proliferation, triggers humoral immune responses, activates NF-kB, and induces cell death. APRIL and its receptors BCMA and TACI are involved in autoimmunity and cancer.