GSK575594A

GSK575594A is a modulator of the nicotinic acetylcholine receptor (nAChR) in Ascaris suum. GSK575594A enhances muscle contractions induced by acetylcholine (ACh) by binding to the allosteric binding site between subunits within the transmembrane domain of nAChR. At a concentration of 3 μM, GSK575594A significantly increased the contraction induced by ACh in Ascaris suum (Emax increased from 1.19 g to 1.51 g) . GSK575594A may be used in research within the field of antiparasitic studies[1].

Product Specifications

CAS Number

[909418-68-4]

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

NAChR; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/gsk575594a.html

Smiles

O=C(N1CCN(C2=CC=C(N)C=C2F)CC1)C3=CC(S(=O)(C)=O)=CC=C3C4=CC=C(F)C=C4

Molecular Formula

C24H23F2N3O3S

Molecular Weight

471.52

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]Stevanovic S, et al. Potential modulating effect of the Ascaris suum nicotinic acetylcholine receptor (nAChR) by compounds GSK575594A, diazepam and flumazenil discovered by structure-based virtual screening approach. Mol Biochem Parasitol. 2021 Mar;242:111350.