NAV 26
NAV 26 (compound 26) is a selective voltage-gated sodium channel Nav1.7 blocker with an IC50 of 0.37 μM. NAV 26 can be used for pain research[1].
Product Specifications
CAS Number
[1198160-14-3]
Product Name Alternative
d,l-SKF89976A hydrochloride
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nav-26.html
Purity
99.79
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1C2=CC=CC=C2C(N1C3CCOCC3)C(NCC4=CC=C(C=C4)OC(F)(F)F)=O
Molecular Formula
C22H21F3N2O4
Molecular Weight
434.41
References & Citations
[1]Istvan Macsari, et al. 3-Oxoisoindoline-1-carboxamides: potent, state-dependent blockers of voltage-gated sodium channel Na (V) 1.7 with efficacy in rat pain models. J Med Chem. 2012 Aug 9;55 (15) :6866-80.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Nav1.7
Available Sizes
Curated Selection
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