Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2
Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2, a bioactive peptide, is a selective Protease activating receptor 1 (PAR-1) agonist over PAR-2. PAR-1 belongs to a subfamily of G-protein coupled receptors and is known to mediate the cellular effects of thrombin. In addition to its varied cellular effects of thrombin, PAR-1 has also been shown to coordinate with PAR-4 and regulate thrombin-induced hepatocellular carcinoma harboring thrombin formation within the tumor environment classified as 'coagulation type'[1].
Product Specifications
CAS Number
211190-38-4
UNSPSC
12352209
Target
Protease Activated Receptor (PAR)
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ala-parafluorophe-arg-cha-cit-tyr-nh2.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](CC1=CC=C(F)C=C1)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC2CCCCC2)C(N[C@@H](CCCNC(N)=O)C(N[C@@H](CC3=CC=C(C=C3)O)C(N)=O)=O)=O)=O)=O)[C@H](C)N
Molecular Formula
C42H63FN12O8
Molecular Weight
883.02
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
PAR1
Frequently Asked Questions
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