SIRT2-IN-13

SIRT2-IN-13 (compound 7c) is an inhibitor of SIRT2 and induces apoptosis. SIRT2-IN-13 selectively inhibits colon cancer and leukemia cells and arrests the cell cycle in the G2 phase[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Sirtuin

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sirt2-in-13.html

Solubility

10 mM in DMSO

Smiles

CN(C)C1=CC(CNCCSC2(C3=CC=CC=C3)C4=C(C=CC=C4)C=CC5=C2C=CC=C5)=NC=C1

Molecular Formula

C31H31N3S

Molecular Weight

477.66

References & Citations

[1]Badran MM, et al. Ligand-based design and synthesis of new trityl histamine and trityl cysteamine derivatives as SIRT2 inhibitors for cancer therapy. Eur J Med Chem. 2024 Mar 7;269:116302.