SIRT2-IN-13
SIRT2-IN-13 (compound 7c) is an inhibitor of SIRT2 and induces apoptosis. SIRT2-IN-13 selectively inhibits colon cancer and leukemia cells and arrests the cell cycle in the G2 phase[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Sirtuin
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sirt2-in-13.html
Solubility
10 mM in DMSO
Smiles
CN(C)C1=CC(CNCCSC2(C3=CC=CC=C3)C4=C(C=CC=C4)C=CC5=C2C=CC=C5)=NC=C1
Molecular Formula
C31H31N3S
Molecular Weight
477.66
References & Citations
[1]Badran MM, et al. Ligand-based design and synthesis of new trityl histamine and trityl cysteamine derivatives as SIRT2 inhibitors for cancer therapy. Eur J Med Chem. 2024 Mar 7;269:116302.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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