SGC8158

SGC8158 is an inhibitor of PRMT7 and can be used to study the cellular function of PRMT7. SGC8158 decreases monomethylarginine levels of Hsp70 (the best characterized PRMT7 substrate) . SGC8158 induces growth inhibition in various cancer cells (IC50: 2-9 μM), as well as multidrug-resistant (MDR) cancer cells. SGC8158 also enhances Doxorubicin (HY-15142A) induced DNA damage and Its cytotoxicity[1].

Product Specifications

UNSPSC

12352005

Target

Histone Methyltransferase; HSP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sgc8158.html

Purity

97.6

Smiles

O[C@H]1[C@@H](O)[C@H](N2C(N=CN=C3N)=C3N=C2)O[C@@H]1CSCCCCNCC4=CC=CC(C5=CC=C(Cl)C=C5)=C4

Molecular Formula

C27H31ClN6O3S

Molecular Weight

555.09

References & Citations

[1]Jeong A, et al. PRMT7 Inhibitor SGC8158 Enhances Doxorubicin-Induced DNA Damage and Its Cytotoxicity. Int J Mol Sci. 2022 Oct 14;23 (20) :12323.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PRMT7

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

NBP2-50464FR 0.1 mL

Mouse Monoclonal DC-LAMP Antibody (L3P2H10/E3) [DyLight 680]

Ask

View Details

GWB-230928 0.05 mL

EGFR Antibody

Ask

View Details

042451-AP 200 µL

SUB1, ID (SUB1, PC4, RPO2TC1, Activated RNA polymerase II transcriptional coactivator p15, Positive cofactor 4, SUB1 homolog, p14) (AP) discontinued

Ask

View Details