SGC8158

SGC8158 is an inhibitor of PRMT7 and can be used to study the cellular function of PRMT7. SGC8158 decreases monomethylarginine levels of Hsp70 (the best characterized PRMT7 substrate) . SGC8158 induces growth inhibition in various cancer cells (IC50: 2-9 μM), as well as multidrug-resistant (MDR) cancer cells. SGC8158 also enhances Doxorubicin (HY-15142A) induced DNA damage and Its cytotoxicity[1].

Product Specifications

UNSPSC

12352005

Target

Histone Methyltransferase; HSP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sgc8158.html

Purity

97.6

Smiles

O[C@H]1[C@@H](O)[C@H](N2C(N=CN=C3N)=C3N=C2)O[C@@H]1CSCCCCNCC4=CC=CC(C5=CC=C(Cl)C=C5)=C4

Molecular Formula

C27H31ClN6O3S

Molecular Weight

555.09

References & Citations

[1]Jeong A, et al. PRMT7 Inhibitor SGC8158 Enhances Doxorubicin-Induced DNA Damage and Its Cytotoxicity. Int J Mol Sci. 2022 Oct 14;23 (20) :12323.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PRMT7

Available Sizes

Curated Selection

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