HUP1-IN-1

HUP1-IN-1 is a hUP1 inhibitor with Kii and Kis Urd of 375 and 635 nM. hUP1-IN-1 showes inhibitory activities over hUP1 catalyzed reaction with 70% at 1 μM. hUP1-IN-1 can be used for the research of cancer.[1]

Product Specifications

CAS Number

[5444-02-0]

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hup1-in-1.html

Solubility

10 mM in DMSO

Smiles

CC1=CC(O)=NC(O)=C1C#N

Molecular Formula

C7H6N2O2

Molecular Weight

150.13

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

References & Citations

[1]Renck D, et al. Design of novel potent inhibitors of human uridine phosphorylase-1: synthesis, inhibition studies, thermodynamics, and in vitro influence on 5-fluorouracil cytotoxicity. J Med Chem. 2013 Nov 14;56 (21) :8892-902.