Thalidomide-NH- (CH2) 3-NH-Boc

Thalidomide-NH- (CH2) 3-NH-Boc is a Boc-modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The Boc protecting group at the end of Thalidomide-NH- (CH2) 3-NH-Boc can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-NH- (CH2) 3-NH-Boc is a key intermediate in the synthesis of CRBN-based designed PROTAC molecules targeting 11β-substituted estradiol.

Product Specifications

CAS Number

[2093386-36-6]

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/thalidomide-nh-ch2-3-nh-boc.html

Solubility

10 mM in DMSO

Smiles

O=C(OC(C)(C)C)NCCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O

Molecular Formula

C21H26N4O6

Molecular Weight

430.45

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512 (7512) :49-53. [Content Brief]