Dichlorobenzamil

Dichlorobenzamil (3',4'-Dichlorobenzamil; L-594881) is an effective Na/Ca exchange inhibitor. Dichlorobenzamil significantly inhibits 45Ca uptake mediated by reverse Na/Ca exchange in pancreatic islet cells (IC50 = 18 μM) . Dichlorobenzamil can also block K+ channels and voltage-sensitive Ca2+ channels[1].

Product Specifications

CAS Number

[1166-01-4]

Product Name Alternative

3',4'-Dichlorobenzamil; L-594881

UNSPSC

12352005

Target

Calcium Channel; Na+/Ca2+ Exchanger; Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/dichlorobenzamil.html

Smiles

O=C(C1=NC(Cl)=C(N)N=C1N)NC(NCC2=CC=C(C(Cl)=C2)Cl)=N

Molecular Formula

C13H12Cl3N7O

Molecular Weight

388.64

References & Citations

[1]Plasman P O, et al. Inhibition of Na/Ca exchange in pancreatic islet cells by 3′, 4′-dichlorobenzamil[J]. Biochemical pharmacology, 1991, 41 (11) : 1759-1768.