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Stercobilin hydrochloride (mixture of isomers)

Stercobilin hydrochloride (amixture of isomers) is a bile pigment metabolized by gut bacteria, and it's also an HIV protease inhibitor, with a Ki of 4 μM. Stercobilin hydrochloride (a mixture of isomers) can induce pro-inflammatory activity in mouse macrophage RAW264 cells, including the production of TNF-α and IL-1β. Stercobilin hydrochloride (a mixture of isomers) can be used in studies of inflammation and viral infections[1][2].

Product Specifications

CAS Number

13129-80-1

UNSPSC

12352200

Target

HIV Protease

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/stercobilin-hydrochloride-mixture-of-isomers.html

Smiles

OC(CCC(C(C)=C(N1)C[C@H]2[C@@H]([C@H](C(N2)=O)C)CC)=C1/C=C3C(CCC(O)=O)=C(C(C[C@H]4[C@@H]([C@H](C(N4)=O)CC)C)=N/3)C)=O.Cl

Molecular Formula

C33H47ClN4O6

Molecular Weight

631.20

References & Citations

[1]Sanada S, et al. Intestinal microbial metabolite stercobilin involvement in the chronic inflammation of ob/ob mice. Sci Rep. 2020 Apr 15;10 (1) :6479. |[2]McPhee F, Caldera PS, Bemis GW, McDonagh AF, Kuntz ID, Craik CS. Bile pigments as HIV-1 protease inhibitors and their effects on HIV-1 viral maturation and infectivity in vitro. Biochem J. 1996 Dec 1;320 (Pt 2) (Pt 2) :681-6.

Shipping Conditions

Room temperature

Scientific Category

Biochemical Assay Reagents

Clinical Information

No Development Reported

Frequently Asked Questions

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