Moclobemide

Moclobemide (Ro111163) is a brain-penetrant and reversible monoamine oxidase (MAO-A) inhibitor with an IC50 of 6.061 μM for hMAO-A[1].Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice.

Product Specifications

CAS Number

[71320-77-9]

Product Name Alternative

Ro111163

UNSPSC

12352005

Hazard Statement

H302, H315, H318, H335

Target

Monoamine Oxidase

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Moclobemide.html

Purity

99.12

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NCCN1CCOCC1)C2=CC=C(Cl)C=C2

Molecular Formula

C13H17ClN2O2

Molecular Weight

268.74

Precautions

H302, H315, H318, H335

References & Citations

[1]Nafiz Öncü Can, et al. Synthesis of New Hydrazone Derivatives for MAO Enzymes Inhibitory Activity. Molecules. 2017 Aug 20;22 (8) :1381.|[2]Yun-feng Li, et al. Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice. Acta Pharmacol Sin. 2004 Nov;25 (11) :1408-12.