MIK665

MIK665 (S-64315), derived from S63845, is a myeloid cell leukemia sequence 1 (MCL1) inhibitor[1]. MIK665 has an IC50 of 1.81 nM for MCL1[2].

Product Specifications

CAS Number

[1799631-75-6]

Product Name Alternative

S-64315

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bcl-2 Family

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/MIK665.html

Purity

99.11

Solubility

DMSO : ≥ 125 mg/mL

Smiles

OC([C@@H](CC(C=CC=C1)=C1OCC2=CC=NC(C3=CC=CC=C3OC)=N2)OC4=C5[C@]([C@]6=C(C)C(Cl)=C(OCCN7CCN(C)CC7)C=C6)=C(C8=CC=C(F)C=C8)SC5=NC=N4)=O

Molecular Formula

C47H44ClFN6O6S

Molecular Weight

875.41

Precautions

H302, H315, H319, H335

References & Citations

[1]Zoltán SZLÁVIK, et al. New hydroxyester derivatives, a process for their preparation and pharmaceutical compositions containing them. WO2016207225A1.|[2]Mukherjee N, et al. Simultaneously Inhibiting BCL2 and MCL1 Is a Therapeutic Option for Patients with Advanced Melanoma. Cancers (Basel) . 2020;12 (8) :2182. Published 2020 Aug 5.