Nivalenol

Nivalenol, classified as type B trichotecenes toxins produced by Fusarium graminearum, is a fungal metabolite present in agricultural product[1]. Nivalenol induces cell death through caspase-dependent mechanisms and via the intrinsic apoptotic pathway. Nivalenol affects the immune system, causes emesis, growth retardation, reproductive disorders and has a haematotoxic/myelotoxic effect[2].

Product Specifications

CAS Number

[23282-20-4]

UNSPSC

12352005

Hazard Statement

H225, H302+H312+H332, H319

Target

Antibiotic; Apoptosis; Bacterial; Caspase

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/nivalenol.html

Purity

99.24

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC12C3(CO3)[C@@](O[C@@]4([H])[C@]2(CO)[C@@H](C(C(C)=C4)=O)O)([H])[C@H](O)[C@H]1O

Molecular Formula

C15H20O7

Molecular Weight

312.32

Precautions

H225, H302+H312+H332, H319

References & Citations

[1]Bryła M, et al. Natural Occurrence of Nivalenol, Deoxynivalenol, and Deoxynivalenol-3-Glucoside in Polish Winter Wheat. Toxins (Basel) . 2018 Feb 13;10 (2) .|[2]Aupanun S, et al. Individual and combined mycotoxins deoxynivalenol, nivalenol, and fusarenon-X induced apoptosis in lymphoid tissues of mice after oral exposure. Toxicon. 2019 Jul;165:83-94.