PKMYT1-IN-3
PKMYT1-IN-3 (compound 8ma) is a potent and selective PKMYT1 inhibitor with an IC50 value of 16.5 nM. PKMYT1-IN-3 has antitumor activity[1].
Product Specifications
UNSPSC
12352005
Target
Wee1
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pkmyt1-in-3.html
Smiles
CC1=CC=C(C(C)=C1C2=C(C(C(N)=O)=CC(C3=CC(N4CC[C@H](C4)N)=NC(F)=C3)=C2)N)O
Molecular Formula
C24H26FN5O2
Molecular Weight
435.49
References & Citations
[1]Wang C, et al. Structure-Based Drug Design of 2-Amino-[1,1'-biphenyl]-3-carboxamide Derivatives as Selective PKMYT1 Inhibitors for the Treatment of CCNE1-Amplified Breast Cancer. J Med Chem. 2024 Sep 12;67 (17) :15816-15836.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PKMYT1
Curated Selection
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